岡山大学 薬学部・大学院医歯薬学総合研究科(薬学系)
天然物化学分野
天然物化学分野
原著論文
2023
● Evaluating the activity of N-89 as an oral antimalarial drug
Aly, N. S. M.; Matsumori, H.; Thi Dinh, Q.; Sato, A.; Miyoshi, S.; Chang, K.; Yu, H. S.; Kubota, T.; Kurosaki, Y.; Cao, D. T.; Rashed, G. A.; Kim, H.
Parasites Hosts Dis. 2023, 61, 282–291. DOI: https//doi.org/10.3347/PHD.23044
2022
● Zamamiphidins B and C, new manzamine-related alkaloids from an Amphimedon sp. marine sponge collected in Okinawa
Kurimoto, S.; Suzuki, S.; Ueno, M.; Fromont, J.; Kobayashi, J.; Kubota, T.
J. Nat. Prod. 2022, 85, 2226–2231. DOI: 10.1021/acs.jnatprod.2c00395
2023
● Evaluating the activity of N-89 as an oral antimalarial drug
Aly, N. S. M.; Matsumori, H.; Thi Dinh, Q.; Sato, A.; Miyoshi, S.; Chang, K.; Yu, H. S.; Kubota, T.; Kurosaki, Y.; Cao, D. T.; Rashed, G. A.; Kim, H.
Parasites Hosts Dis. 2023, 61, 282–291. DOI: https//doi.org/10.3347/PHD.23044
2022
● Zamamiphidins B and C, new manzamine-related alkaloids from an Amphimedon sp. marine sponge collected in Okinawa
Kurimoto, S.; Suzuki, S.; Ueno, M.; Fromont, J.; Kobayashi, J.; Kubota, T.
J. Nat. Prod. 2022, 85, 2226–2231. DOI: 10.1021/acs.jnatprod.2c00395
● Ma'edamines E and F, rare bromotyrosine alkaloids possessing a 1,2,3,5-tetrasubstituted pyridinium moiety from an Okinawan marine sponge Suberea sp.
Kurimoto, S.; Okamoto, A.; Seino, S.; Fromont, J.; Kobayashi, J.; Kubota, T.
Tetrahedron Lett. 2022, 103, 153985. DOI: 10.1016/j.tetlet.2022.153985
● Teuchamaedol A, a new neo-clerodane diterpenoid from the aerial parts of Teucrium chamaedrys
Kurimoto, S.; Wakabayashi, K.; Sasaki, Y. F.; Nakamura, T.; Kubota, T.
Tetrahedron Lett. 2022, 100, 153890. DOI: 10.1016/j.tetlet.2022.153890
● Macrocarquinoid D, new meroterpenoid from brown alga, Sargassum macrocarpum
Shinoda, S.; Kurimoto, S.; Kubota, T.; Sekiguchi, M.
Heterocycles 2022, 104, 1141–1147. DOI: 10.3987/COM-22-14651
2021
● Macrocarquinoids A–C, new meroterpenoids from Sargassum macrocarpum
Niwa, H.; Kurimoto, S.; Kubota, T.; Sekiguchi, M.
J. Nat. Med. 2021, 75, 194–200. DOI: 10.1007/s11418-020-01449-y
● Kamiohnoyneosides A and B, two new polyacetylene glycosides from flowers of edible Chrysanthemum "Kamiohno"
Kurimoto, S.; Fujita, H.; Kawaguchi, S.; Sasaki, Y. F.; Nakamura, T.; Kubota, T.
J. Nat. Med. 2021, 75, 167–172. DOI: 10.1007/s11418-020-01443-4
2020
● Integrated omics unveils the multifaceted secondary metabolism landscape of a basal dinoflagellate
Beedessee, G.; Kubota, T.; Arimoto, A.; Nishitsuji, K.; Waller, R. F.; Hisata, K.; Yamasaki, S.; Satoh, N.; Kobayashi, J.; Shoguchi, E.
BMC Biol. 2020, 18, 139. DOI: 10.1186/s12915-020-00873-6
2019
● Ma'edamines C and D, new bromotyrosine alkaloids possessing a unique tetrasubstituted pyridinium moiety from an Okinawan marine sponge Suberea sp.
Kurimoto, S.; Seino, S.; Fromont, J.; Kobayashi, J.; Kubota, T.
Org. Lett. 2019, 21, 8824–8826. DOI: 10.1021/acs.orglett.9b03457
Kurimoto, S.; Okamoto, A.; Seino, S.; Fromont, J.; Kobayashi, J.; Kubota, T.
Tetrahedron Lett. 2022, 103, 153985. DOI: 10.1016/j.tetlet.2022.153985
● Teuchamaedol A, a new neo-clerodane diterpenoid from the aerial parts of Teucrium chamaedrys
Kurimoto, S.; Wakabayashi, K.; Sasaki, Y. F.; Nakamura, T.; Kubota, T.
Tetrahedron Lett. 2022, 100, 153890. DOI: 10.1016/j.tetlet.2022.153890
● Macrocarquinoid D, new meroterpenoid from brown alga, Sargassum macrocarpum
Shinoda, S.; Kurimoto, S.; Kubota, T.; Sekiguchi, M.
Heterocycles 2022, 104, 1141–1147. DOI: 10.3987/COM-22-14651
2021
● Macrocarquinoids A–C, new meroterpenoids from Sargassum macrocarpum
Niwa, H.; Kurimoto, S.; Kubota, T.; Sekiguchi, M.
J. Nat. Med. 2021, 75, 194–200. DOI: 10.1007/s11418-020-01449-y
● Kamiohnoyneosides A and B, two new polyacetylene glycosides from flowers of edible Chrysanthemum "Kamiohno"
Kurimoto, S.; Fujita, H.; Kawaguchi, S.; Sasaki, Y. F.; Nakamura, T.; Kubota, T.
J. Nat. Med. 2021, 75, 167–172. DOI: 10.1007/s11418-020-01443-4
2020
● Integrated omics unveils the multifaceted secondary metabolism landscape of a basal dinoflagellate
Beedessee, G.; Kubota, T.; Arimoto, A.; Nishitsuji, K.; Waller, R. F.; Hisata, K.; Yamasaki, S.; Satoh, N.; Kobayashi, J.; Shoguchi, E.
BMC Biol. 2020, 18, 139. DOI: 10.1186/s12915-020-00873-6
2019
● Ma'edamines C and D, new bromotyrosine alkaloids possessing a unique tetrasubstituted pyridinium moiety from an Okinawan marine sponge Suberea sp.
Kurimoto, S.; Seino, S.; Fromont, J.; Kobayashi, J.; Kubota, T.
Org. Lett. 2019, 21, 8824–8826. DOI: 10.1021/acs.orglett.9b03457
2018
● Ceratinadins E and F, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp.
Kurimoto, S.; Ohno, T.; Hokari, R.; Ishiyama, A.; Iwatsuki, M.; Ōmura, S.; Kobayashi, J.; Kubota, T.
Mar. Drugs 2018, 16, 463. DOI: 10.3390/md16120463
● Ceratinadins E and F, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp.
Kurimoto, S.; Ohno, T.; Hokari, R.; Ishiyama, A.; Iwatsuki, M.; Ōmura, S.; Kobayashi, J.; Kubota, T.
Mar. Drugs 2018, 16, 463. DOI: 10.3390/md16120463
● Ishigadine A, a new canthin-6-one alkaloid from an Okinawan marine sponge Hyrtios sp.
Takahashi, H.; Kurimoto, S.; Kobayashi, J.; Kubota, T.
Tetrahedron Lett. 2018, 59, 4500–4502. DOI: 10.1016/j.tetlet.2018.11.019
Takahashi, H.; Kurimoto, S.; Kobayashi, J.; Kubota, T.
Tetrahedron Lett. 2018, 59, 4500–4502. DOI: 10.1016/j.tetlet.2018.11.019
● Symbiodinolactone A, a new 12-membered macrolide from symbiotic marine dinoflagellate Symbiodinium sp.
Kurimoto, S.; Iinuma, Y.; Kobayashi, J.; Kubota, T.
Tetrahedron Lett. 2018, 59, 4496–4499. DOI: 10.1016/j.tetlet.2018.11.018
Kurimoto, S.; Iinuma, Y.; Kobayashi, J.; Kubota, T.
Tetrahedron Lett. 2018, 59, 4496–4499. DOI: 10.1016/j.tetlet.2018.11.018
2017
● New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities
Nguyen, H. M.; Ito, T.; Kurimoto, S.; Ogawa, M.; Win, N. N.; Hung, V. Q.; Nguyen, H. T.; Kubota, T.; Kobayashi, J.; Morita, H.
Bioorg. Med. Chem. Lett. 2017, 27, 3043–3047. DOI: 10.1016/j.bmcl.2017.05.060
● Zamamidine D, a manzamine alkaloid from an Okinawan Amphimedon sp. marine sponge
Kubota, T.; Nakamura, K.; Kurimoto, S.; Sakai, K.; Fromont, J.; Gonoi, T.; Kobayashi, J.
J. Nat. Prod. 2017, 80, 1196–1199. DOI: 10.1021/acs.jnatprod.6b01110
● New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities
Nguyen, H. M.; Ito, T.; Kurimoto, S.; Ogawa, M.; Win, N. N.; Hung, V. Q.; Nguyen, H. T.; Kubota, T.; Kobayashi, J.; Morita, H.
Bioorg. Med. Chem. Lett. 2017, 27, 3043–3047. DOI: 10.1016/j.bmcl.2017.05.060
● Zamamidine D, a manzamine alkaloid from an Okinawan Amphimedon sp. marine sponge
Kubota, T.; Nakamura, K.; Kurimoto, S.; Sakai, K.; Fromont, J.; Gonoi, T.; Kobayashi, J.
J. Nat. Prod. 2017, 80, 1196–1199. DOI: 10.1021/acs.jnatprod.6b01110
● Stylissamide I, a new cyclic heptapeptide from an Okinawan marine sponge Stylissa sp.
Kubota, T.; Nakamura, K.; Kurimoto, S.; Sakai, K.; Fromont, J.; Gonoi, T.; Kobayashi, J.
Heterocycles 2017, 95, 799–806. DOI: 10.3987/COM-16-S(S)45
Kubota, T.; Nakamura, K.; Kurimoto, S.; Sakai, K.; Fromont, J.; Gonoi, T.; Kobayashi, J.
Heterocycles 2017, 95, 799–806. DOI: 10.3987/COM-16-S(S)45
2016
● Biosynthetic study of amphidinin A and amphidinolide P
Kubota, T.; Sato, H.; Iwai, T.; Kobayashi, J.
Chem. Pharm. Bull. 2016, 64, 979–981. DOI: 10.1248/cpb.c16-00202
● Hyrtinadines C and D, new azepino-indole-type alkaloids from an Okinawan marine sponge Hyrtios sp.
Kubota, T.; Nakamura, K.; Sakai, K.; Fromont, J.; Gonoi, T.; Kobayashi, J.
Chem. Pharm. Bull. 2016, 64, 975–978. DOI: 10.1248/cpb.c16-00201
● Biosynthetic study of amphidinin A and amphidinolide P
Kubota, T.; Sato, H.; Iwai, T.; Kobayashi, J.
Chem. Pharm. Bull. 2016, 64, 979–981. DOI: 10.1248/cpb.c16-00202
● Hyrtinadines C and D, new azepino-indole-type alkaloids from an Okinawan marine sponge Hyrtios sp.
Kubota, T.; Nakamura, K.; Sakai, K.; Fromont, J.; Gonoi, T.; Kobayashi, J.
Chem. Pharm. Bull. 2016, 64, 975–978. DOI: 10.1248/cpb.c16-00201
● Total synthesis of the 7,10-epimer of the proposed structure of amphidinolide N, part II: synthesis of C17-C29 subunit and completion of the synthesis
Ochiai, K.; Kuppusamy, S.; Yasui, Y.; Harada, K.; Gupta, N. R.; Takahashi, Y.; Kubota, T.; Kobayashi, J.; Hayashi, Y.
Chem. Eur. J. 2016, 22, 3287–3291. DOI: 10.1002/chem.201504674
● Total synthesis of the 7,10-epimer of the proposed structure of amphidinolide N, part I: synthesis of the C1-C13 subunit
Ochiai, K.; Kuppusamy, S.; Yasui, Y.; Okano, T.; Matsumoto, Y.; Gupta, N. R.; Takahashi, Y.; Kubota, T.; Kobayashi, J.; Hayashi, Y.
Chem. Eur. J. 2016, 22, 3282–3286. DOI: 10.1002/chem.201504675
2015
● Tyrokeradines G and H, new bromotyrosine alkaloids from an Okinawan Verongid sponge
Kubota, T.; Watase, S.; Sakai, K.; Fromont, J.; Gonoi, T.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2015, 25, 5221–5223. DOI: 10.1016/j.bmcl.2015.09.061.
Ochiai, K.; Kuppusamy, S.; Yasui, Y.; Harada, K.; Gupta, N. R.; Takahashi, Y.; Kubota, T.; Kobayashi, J.; Hayashi, Y.
Chem. Eur. J. 2016, 22, 3287–3291. DOI: 10.1002/chem.201504674
● Total synthesis of the 7,10-epimer of the proposed structure of amphidinolide N, part I: synthesis of the C1-C13 subunit
Ochiai, K.; Kuppusamy, S.; Yasui, Y.; Okano, T.; Matsumoto, Y.; Gupta, N. R.; Takahashi, Y.; Kubota, T.; Kobayashi, J.; Hayashi, Y.
Chem. Eur. J. 2016, 22, 3282–3286. DOI: 10.1002/chem.201504675
2015
● Tyrokeradines G and H, new bromotyrosine alkaloids from an Okinawan Verongid sponge
Kubota, T.; Watase, S.; Sakai, K.; Fromont, J.; Gonoi, T.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2015, 25, 5221–5223. DOI: 10.1016/j.bmcl.2015.09.061.
● Cyclopiazonic acid biosynthesis gene cluster gene cpaM is required for speradine A biosynthesis
Tokuoka, M.; Kikuchi, T.; Shinohara, Y.; Koyama, A.; Iio, S.; Kubota, T.; Kobayashi, J.; Koyama, Y.; Totsuka, A.; Shindo, H.; Sato, K.
Biosci. Biotechnol. Biochem. 2015, 79, 2081–2085. DOI: 10.1080/09168451.2015.1065167
● Amphidinin G, a putative precursor of amphidinin A from marine dinoflagellate Amphidinium sp.
Kubota, T.; Iwai, T.; Ishiyama, H.; Sakai, K.; Gonoi, T.; Kobayashi, J.
Tetrahedron Lett. 2015, 56, 990–993. DOI: 10.1016/j.tetlet.2015.01.058
Tokuoka, M.; Kikuchi, T.; Shinohara, Y.; Koyama, A.; Iio, S.; Kubota, T.; Kobayashi, J.; Koyama, Y.; Totsuka, A.; Shindo, H.; Sato, K.
Biosci. Biotechnol. Biochem. 2015, 79, 2081–2085. DOI: 10.1080/09168451.2015.1065167
● Amphidinin G, a putative precursor of amphidinin A from marine dinoflagellate Amphidinium sp.
Kubota, T.; Iwai, T.; Ishiyama, H.; Sakai, K.; Gonoi, T.; Kobayashi, J.
Tetrahedron Lett. 2015, 56, 990–993. DOI: 10.1016/j.tetlet.2015.01.058
2014
● Iejimalide C is a potent V-ATPase inhibitor, and induces actin disorganization
Kazami, S.; Takaine, M.; Itoh, H.; Kubota, T.; Kobayashi, J.; Usui, T.
Biol. Pharm. Bull. 2014, 37, 1944–1947. DOI: 10.1248/bpb.b14-00548
● Amphidinins C-F, amphidinolide Q analogues from marine dinoflagellate Amphidinium sp.
Kubota, T.; Iwai, T.; Sakai, K.; Gonoi, T.; Kobayashi, J.
Org. Lett. 2014, 16, 5624–5627. DOI: 10.1021/ol502685z
● Iejimalide C is a potent V-ATPase inhibitor, and induces actin disorganization
Kazami, S.; Takaine, M.; Itoh, H.; Kubota, T.; Kobayashi, J.; Usui, T.
Biol. Pharm. Bull. 2014, 37, 1944–1947. DOI: 10.1248/bpb.b14-00548
● Amphidinins C-F, amphidinolide Q analogues from marine dinoflagellate Amphidinium sp.
Kubota, T.; Iwai, T.; Sakai, K.; Gonoi, T.; Kobayashi, J.
Org. Lett. 2014, 16, 5624–5627. DOI: 10.1021/ol502685z
● Absolute configuration of amphidinin A
Iwai, T.; Kubota, T.; Kobayashi, J.
J. Nat. Prod. 2014, 77, 1541–1544. DOI: 10.1021/np5003065
Iwai, T.; Kubota, T.; Kobayashi, J.
J. Nat. Prod. 2014, 77, 1541–1544. DOI: 10.1021/np5003065
● Taurospongins B and C, new acetylenic fatty acid derivatives possessing a taurine amide residue from a marine sponge of the family Spongiidae
Kubota, T.; Suzuki, H.; Takahashi-Nakaguchi, A.; Fromont, J.; Gonoi, T.; Kobayashi, J.
RSC Adv. 2014, 4, 11073–11079. DOI: 10.1039/C3RA47796G
Kubota, T.; Suzuki, H.; Takahashi-Nakaguchi, A.; Fromont, J.; Gonoi, T.; Kobayashi, J.
RSC Adv. 2014, 4, 11073–11079. DOI: 10.1039/C3RA47796G
● Nagelamide I and 2,2'-didebromonagelamide B, new dimeric bromopyrrole-imidazole alkaloids from a marine sponge Agelas sp.
Iwai, T.; Kubota, T.; Fromont, J.; Kobayashi, J.
Chem. Pharm. Bull. 2014, 62, 213–216. DOI: 10.1248/cpb.c13-00821
Iwai, T.; Kubota, T.; Fromont, J.; Kobayashi, J.
Chem. Pharm. Bull. 2014, 62, 213–216. DOI: 10.1248/cpb.c13-00821
● Nakijiquinone S and nakijinol C, new meroterpenoids from a marine sponge of the family Spongiidae
Suzuki, H.; Kubota, T.; Takahashi-Nakaguchi, A.; Fromont, J.; Gonoi, T.; Kobayashi, J.
Chem. Pharm. Bull. 2014, 62, 209–212. DOI: 10.1248/cpb.c13-00810
Suzuki, H.; Kubota, T.; Takahashi-Nakaguchi, A.; Fromont, J.; Gonoi, T.; Kobayashi, J.
Chem. Pharm. Bull. 2014, 62, 209–212. DOI: 10.1248/cpb.c13-00810
2013
● Hyrtimomines D and E, bisindole alkaloids from a marine sponge Hyrtios sp.
Tanaka, N.; Momose, R.; Takahashi, Y.; Kubota, T.; Takahashi-Nakaguchi, A.; Gonoi, T.; Fromont, J.; Kobayashi, J.
Tetrahedron Lett. 2013, 54, 4038–4040. DOI: 10.1016/j.tetlet.2013.05.073
● Revised structure and stereochemical assignments of amphidinolide N
Takahashi, Y.; Kubota, T.; Imachi, M.; Wälchli, M. R.; Kobayashi, J.
J. Antibiot. 2013, 66, 277–279. DOI: 10.1038/ja.2012.117
● Zamamiphidin A, a new manzamine related alkaloid from an Okinawan marine sponge Amphimedon sp.
Kubota, T.; Kamijyo, Y.; Takahashi-Nakaguchi, A.; Fromont, J.; Gonoi, T.; Kobayashi, J.
Org. Lett. 2013, 15, 610–612. DOI: 10.1021/ol3034274
● Hyrtimomines D and E, bisindole alkaloids from a marine sponge Hyrtios sp.
Tanaka, N.; Momose, R.; Takahashi, Y.; Kubota, T.; Takahashi-Nakaguchi, A.; Gonoi, T.; Fromont, J.; Kobayashi, J.
Tetrahedron Lett. 2013, 54, 4038–4040. DOI: 10.1016/j.tetlet.2013.05.073
● Revised structure and stereochemical assignments of amphidinolide N
Takahashi, Y.; Kubota, T.; Imachi, M.; Wälchli, M. R.; Kobayashi, J.
J. Antibiot. 2013, 66, 277–279. DOI: 10.1038/ja.2012.117
● Zamamiphidin A, a new manzamine related alkaloid from an Okinawan marine sponge Amphimedon sp.
Kubota, T.; Kamijyo, Y.; Takahashi-Nakaguchi, A.; Fromont, J.; Gonoi, T.; Kobayashi, J.
Org. Lett. 2013, 15, 610–612. DOI: 10.1021/ol3034274
● Stereochemistry of theonezolides A-C
Nozawa, K.; Tsuda, M.; Tanaka, N.; Kubota, T.; Fukushi, E.; Kawabata, J.; Kobayashi, J.
Tetrahedron Lett. 2013, 54, 783–787. DOI: 10.1016/j.tetlet.2012.11.120
● Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.
Kubota, T.; Ishiguro, Y.; Takahashi-Nakaguchi, A.; Fromont, J.; Gonoi, T.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2013, 23, 244–247. DOI: 10.1016/j.bmcl.2012.10.109
Nozawa, K.; Tsuda, M.; Tanaka, N.; Kubota, T.; Fukushi, E.; Kawabata, J.; Kobayashi, J.
Tetrahedron Lett. 2013, 54, 783–787. DOI: 10.1016/j.tetlet.2012.11.120
● Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.
Kubota, T.; Ishiguro, Y.; Takahashi-Nakaguchi, A.; Fromont, J.; Gonoi, T.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2013, 23, 244–247. DOI: 10.1016/j.bmcl.2012.10.109
● Inhibitory effects of metachromins L-Q and its related analogs against receptor tyrosine kinases EGFR and HER2
Takahashi, Y.; Kubota, T.; Yamamoto, S.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2013, 23, 117–118. DOI: 10.1016/j.bmcl.2012.11.001
● Pyrinodemins G-I, new bis-3-alkylpyridine alkaloids from a marine sponge Amphimedon sp.
Kubota, T.; Kura, K.; Fromont, J.; Kobayashi, J.
Tetrahedron 2013, 69, 96–100. DOI: 10.1016/j.tet.2012.10.062
Takahashi, Y.; Kubota, T.; Yamamoto, S.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2013, 23, 117–118. DOI: 10.1016/j.bmcl.2012.11.001
● Pyrinodemins G-I, new bis-3-alkylpyridine alkaloids from a marine sponge Amphimedon sp.
Kubota, T.; Kura, K.; Fromont, J.; Kobayashi, J.
Tetrahedron 2013, 69, 96–100. DOI: 10.1016/j.tet.2012.10.062
2012
● Tyrokeradines C-F, new bromotyrosine alkaloids from the Verongid sponges
Kubota, T.; Watase, S.; Mukai, H.; Fromont, J.; Kobayashi, J.
Chem. Pharm. Bull. 2012, 60, 1599–1601. DOI:10.1248/cpb.c12-00785
● Tyrokeradines C-F, new bromotyrosine alkaloids from the Verongid sponges
Kubota, T.; Watase, S.; Mukai, H.; Fromont, J.; Kobayashi, J.
Chem. Pharm. Bull. 2012, 60, 1599–1601. DOI:10.1248/cpb.c12-00785
● Agelasines O-U, new diterpene alkaloids with a 9-N-methyladenine unit from a marine sponge Agelas sp.
Kubota, T.; Iwai, T.; Takahashi-Nakaguchi, A.; Fromont, J.; Gonoi, T.; Kobayashi, J.
Tetrahedron 2012, 68, 9738–9744. DOI: 10.1016/j.tet.2012.09.040
Kubota, T.; Iwai, T.; Takahashi-Nakaguchi, A.; Fromont, J.; Gonoi, T.; Kobayashi, J.
Tetrahedron 2012, 68, 9738–9744. DOI: 10.1016/j.tet.2012.09.040
● Heteroaromatic alkaloids, nakijinamines, from a sponge Suberites sp.
Takahashi, Y.; Tanaka, N.; Kubota, T.; Ishiyama, H.; Shibazaki, A.; Gonoi, T.; Fromont, J.; Kobayashi, J.
Tetrahedron 2012, 68, 8545–8550. DOI: 10.1016/j.tet.2012.08.018
● Halichonadins K and L, new dimeric sesquiterpenoids from a sponge Halichondria sp.
Tanaka, N.; Suto, S.; Ishiyama, H.; Kubota, T.; Yamano, A.; Shiro, M.; Fromont, J.; Kobayashi, J.
Org. Lett. 2012, 14, 3498–3501. DOI: 10.1021/ol3014705
2011
● Eudistomidins H-K, new β-carborine alkaloids from the Okinawan marine tunicate Eudistoma glaucus
Suzuki, T.; Kubota, T.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2011, 21, 4220–4223. DOI: 10.1016/j.bmcl.2011.05.072
● Nakijinamines C-E, new heteroaromatic alkaloids from the sponge Suberites species
Takahashi, Y.; Kubota, T.; Shibazaki, A.; Gonoi, T.; Fromont, J.; Kobayashi, J.
Org. Lett. 2011, 13, 3016–3019. DOI: 10.1021/ol2008473
● Hyrtioseragamines A and B, new alkaloids from the sponge Hyrtios species
Takahashi, Y.; Iinuma, Y.; Kubota, T.; Tsuda, M.; Sekiguchi, M.; Mikami, Y.; Fromont, J.; Kobayashi, J.
Org. Lett. 2011, 13, 628–631. DOI: 10.1021/ol102867x
Takahashi, Y.; Tanaka, N.; Kubota, T.; Ishiyama, H.; Shibazaki, A.; Gonoi, T.; Fromont, J.; Kobayashi, J.
Tetrahedron 2012, 68, 8545–8550. DOI: 10.1016/j.tet.2012.08.018
● Halichonadins K and L, new dimeric sesquiterpenoids from a sponge Halichondria sp.
Tanaka, N.; Suto, S.; Ishiyama, H.; Kubota, T.; Yamano, A.; Shiro, M.; Fromont, J.; Kobayashi, J.
Org. Lett. 2012, 14, 3498–3501. DOI: 10.1021/ol3014705
2011
● Eudistomidins H-K, new β-carborine alkaloids from the Okinawan marine tunicate Eudistoma glaucus
Suzuki, T.; Kubota, T.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2011, 21, 4220–4223. DOI: 10.1016/j.bmcl.2011.05.072
● Nakijinamines C-E, new heteroaromatic alkaloids from the sponge Suberites species
Takahashi, Y.; Kubota, T.; Shibazaki, A.; Gonoi, T.; Fromont, J.; Kobayashi, J.
Org. Lett. 2011, 13, 3016–3019. DOI: 10.1021/ol2008473
● Hyrtioseragamines A and B, new alkaloids from the sponge Hyrtios species
Takahashi, Y.; Iinuma, Y.; Kubota, T.; Tsuda, M.; Sekiguchi, M.; Mikami, Y.; Fromont, J.; Kobayashi, J.
Org. Lett. 2011, 13, 628–631. DOI: 10.1021/ol102867x
● Lyconadins D and E, and complanadine E, new Lycopodiumalkaloids from Lycopodium complanatum
Ishiuchi, K.; Kubota, T.; Ishiyama, H.; Hayashi, S.; Shibata, T.; Mori, K.; Obara, Y.; Nakahata, N.; Kobayashi, J.
Bioorg. Med. Chem. 2011, 19, 749–753. DOI: 10.1016/j.bmc.2010.12.025
● Lyconadins C and F, new Lycopodium alkaloids from Lycopodium complanatum
Ishiuchi, K.; Kubota, T.; Ishiyama, H.; Hayashi, S.; Shibata, T.; Kobayashi, J.
Tetrahedron Lett. 2011, 52, 289–292. DOI: 10.1016/j.tetlet.2010.11.024
● Pyrinodemins E and F, new 3-alkylpyridine alkaloids from sponge Amphimedon sp.
Kura, K.; Kubota, T.; Fromont, J.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2011, 21, 267–270. DOI: 10.1016/j.bmcl.2010.11.020
2010
● Amphidinolide C3, a cytotoxic new 25-membered macrolide from marine dinoflagellate Amphidinium sp.
Kubota, T.; Suzuki, A.; Yamada, M.; Baba, S.; Kobayashi, J.
Heterocycles 2010, 82, 333–338. DOI: 10.3987/COM-10-S(E)3
● Ceratinadins A-C, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp.
Kon, Y.; Kubota, T.; Shibazaki, A.; Gonoi, T.; Fromont, J.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2010, 20, 4569–4572. DOI: 10.1016/j.bmcl.2010.06.015
Ishiuchi, K.; Kubota, T.; Ishiyama, H.; Hayashi, S.; Shibata, T.; Mori, K.; Obara, Y.; Nakahata, N.; Kobayashi, J.
Bioorg. Med. Chem. 2011, 19, 749–753. DOI: 10.1016/j.bmc.2010.12.025
● Lyconadins C and F, new Lycopodium alkaloids from Lycopodium complanatum
Ishiuchi, K.; Kubota, T.; Ishiyama, H.; Hayashi, S.; Shibata, T.; Kobayashi, J.
Tetrahedron Lett. 2011, 52, 289–292. DOI: 10.1016/j.tetlet.2010.11.024
● Pyrinodemins E and F, new 3-alkylpyridine alkaloids from sponge Amphimedon sp.
Kura, K.; Kubota, T.; Fromont, J.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2011, 21, 267–270. DOI: 10.1016/j.bmcl.2010.11.020
2010
● Amphidinolide C3, a cytotoxic new 25-membered macrolide from marine dinoflagellate Amphidinium sp.
Kubota, T.; Suzuki, A.; Yamada, M.; Baba, S.; Kobayashi, J.
Heterocycles 2010, 82, 333–338. DOI: 10.3987/COM-10-S(E)3
● Ceratinadins A-C, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp.
Kon, Y.; Kubota, T.; Shibazaki, A.; Gonoi, T.; Fromont, J.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2010, 20, 4569–4572. DOI: 10.1016/j.bmcl.2010.06.015
● Eudistomidin G, a new β-carboline alkaloid from the Okinawan marine tunicate Eudistoma glaucus and structure revision of eudistomidin B
Takahashi, Y.; Ishiyama, H.; Kubota, T.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2010, 20, 4100–4103. DOI: 10.1016/j.bmcl.2010.05.071
● Untenolide A, a new polyketide from an Okinawan marine sponge Plakortis sp.
Ishiguro, Y.; Kubota, T.; Fromont, J.; Shiro, M.; Kobayashi, J.
Tetrahedron Lett. 2010, 51, 4023–4026. DOI: 10.1016/j.tetlet.2010.05.085
Takahashi, Y.; Ishiyama, H.; Kubota, T.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2010, 20, 4100–4103. DOI: 10.1016/j.bmcl.2010.05.071
● Untenolide A, a new polyketide from an Okinawan marine sponge Plakortis sp.
Ishiguro, Y.; Kubota, T.; Fromont, J.; Shiro, M.; Kobayashi, J.
Tetrahedron Lett. 2010, 51, 4023–4026. DOI: 10.1016/j.tetlet.2010.05.085
● Nakijiquinones J-R, sesquiterpenoid quinones with an amine residue from Okinawan marine sponges
Takahashi, Y.; Ushio, M.; Kubota, T.; Yamamoto, S.; Fromont, J.; Kobayashi, J.
J. Nat. Prod. 2010, 73, 467–471. DOI: 10.1021/np900470e
● Platisidines A-C, N-methyl pyridinium alkaloids from an Okinawan marine sponge of Plakortis species
Kubota, T.; Ishiguro, Y.; Yamamoto, S.; Fromont, J.; Kobayashi, J.
Heterocycles 2010, 80, 1407–1412. DOI: 10.3987/COM-09-S(S)131
Takahashi, Y.; Ushio, M.; Kubota, T.; Yamamoto, S.; Fromont, J.; Kobayashi, J.
J. Nat. Prod. 2010, 73, 467–471. DOI: 10.1021/np900470e
● Platisidines A-C, N-methyl pyridinium alkaloids from an Okinawan marine sponge of Plakortis species
Kubota, T.; Ishiguro, Y.; Yamamoto, S.; Fromont, J.; Kobayashi, J.
Heterocycles 2010, 80, 1407–1412. DOI: 10.3987/COM-09-S(S)131
● Biyouxanthones A-D, prenylated xanthones from roots of Hypericum chinense
Tanaka, N.; Mamemura, T.; Abe, S.; Imabayashi, K.; Kashiwada, Y.; Takaishi, Y.; Suzuki, T.; Takebe, Y.; Kubota, T.; Kobayashi, J.
Heterocycles 2010, 80, 613–621. DOI: 10.3987/COM-09-S(S)28
2009
● Benzosceptrin C, a new dimeric bromopyrrole alkaloid from sponge Agelas sp.
Kubota, T.; Araki, A.; Yasuda, T.; Tsuda, M.; Fromont, J.; Aoyama, K.; Mikami, Y.; Wälchli, M. R.; Kobayashi, J.
Tetrahedron Lett. 2009, 50, 7268–7270. DOI: 10.1016/j.tetlet.2009.10.017
Tanaka, N.; Mamemura, T.; Abe, S.; Imabayashi, K.; Kashiwada, Y.; Takaishi, Y.; Suzuki, T.; Takebe, Y.; Kubota, T.; Kobayashi, J.
Heterocycles 2010, 80, 613–621. DOI: 10.3987/COM-09-S(S)28
2009
● Benzosceptrin C, a new dimeric bromopyrrole alkaloid from sponge Agelas sp.
Kubota, T.; Araki, A.; Yasuda, T.; Tsuda, M.; Fromont, J.; Aoyama, K.; Mikami, Y.; Wälchli, M. R.; Kobayashi, J.
Tetrahedron Lett. 2009, 50, 7268–7270. DOI: 10.1016/j.tetlet.2009.10.017
● Lycopladine H, a novel alkaloid with a fused-tetracyclic skeleton from Lycopodium complanatum
Ishiuchi, K.; Kubota, T.; Hayashi, S.; Shibata, T.; Kobayashi, J.
Tetrahedron Lett. 2009, 50, 6534–6536. DOI: 10.1016/j.tetlet.2009.09.035
Ishiuchi, K.; Kubota, T.; Hayashi, S.; Shibata, T.; Kobayashi, J.
Tetrahedron Lett. 2009, 50, 6534–6536. DOI: 10.1016/j.tetlet.2009.09.035
● Petiolins F-I, benzophenone rhamnosides from Hypericum pseudopetiolatum var. kiusianum
Tanaka, N.; Kubota, T.; Kashiwada, Y.; Takaishi, Y.; Kobayashi, J.
Chem. Pharm. Bull. 2009, 57, 1171–1173. DOI: 10.1248/cpb.57.1171
● Lannotinidines H-J, New Lycopodium alkaloids from Lycopodium annotinum
Ishiuchi, K.; Kodama, S.; Kubota, T.; Hayashi, S.; Shibata, T.; Kobayashi, J.
Chem. Pharm. Bull. 2009, 57, 877–881. DOI: 10.1248/cpb.57.877
● Yezo’otogirins A-C, new tricyclic terpenoids from Hypericum yezoense
Tanaka, N.; Kakuguchi, Y.; Ishiyama, H.; Kubota, T.; Kobayashi, J.
Tetrahedron Lett. 2009, 50, 4747–4750. DOI: 10.1016/j.tetlet.2009.06.021
● Serratezomines D and E, new Lycopodium alkaloids from Lycopodium serratum var. serratum
Kubota, T.; Yahata, H.; Hayashi, S.; Shibata, T.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2009, 19, 3577–3580. DOI: 10.1016/j.bmcl.2009.04.146
Tanaka, N.; Kubota, T.; Kashiwada, Y.; Takaishi, Y.; Kobayashi, J.
Chem. Pharm. Bull. 2009, 57, 1171–1173. DOI: 10.1248/cpb.57.1171
● Lannotinidines H-J, New Lycopodium alkaloids from Lycopodium annotinum
Ishiuchi, K.; Kodama, S.; Kubota, T.; Hayashi, S.; Shibata, T.; Kobayashi, J.
Chem. Pharm. Bull. 2009, 57, 877–881. DOI: 10.1248/cpb.57.877
● Yezo’otogirins A-C, new tricyclic terpenoids from Hypericum yezoense
Tanaka, N.; Kakuguchi, Y.; Ishiyama, H.; Kubota, T.; Kobayashi, J.
Tetrahedron Lett. 2009, 50, 4747–4750. DOI: 10.1016/j.tetlet.2009.06.021
● Serratezomines D and E, new Lycopodium alkaloids from Lycopodium serratum var. serratum
Kubota, T.; Yahata, H.; Hayashi, S.; Shibata, T.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2009, 19, 3577–3580. DOI: 10.1016/j.bmcl.2009.04.146
● Lycopladines F and G, new C16N2-type alkaloids with an additional C4N unit from Lycopodium complanatum
Ishiuchi, K.; Kubota, T.; Hayashi, S.; Shibata, T.; Kobayashi, J.
Tetrahedron Lett. 2009, 50, 4221–4224. DOI: 10.1016/j.tetlet.2009.04.139
● Plakoridine C, a novel piperidine alkaloid from an Okinawan marine sponge Plakortis sp.
Ishiguro, Y.; Kubota, T.; Ishiuchi, K.; Fromont, J.; Kobayashi, J.
Tetrahedron Lett. 2009, 50, 3202–3204. DOI: 10.1016/j.tetlet.2009.01.135
Ishiuchi, K.; Kubota, T.; Hayashi, S.; Shibata, T.; Kobayashi, J.
Tetrahedron Lett. 2009, 50, 4221–4224. DOI: 10.1016/j.tetlet.2009.04.139
● Plakoridine C, a novel piperidine alkaloid from an Okinawan marine sponge Plakortis sp.
Ishiguro, Y.; Kubota, T.; Ishiuchi, K.; Fromont, J.; Kobayashi, J.
Tetrahedron Lett. 2009, 50, 3202–3204. DOI: 10.1016/j.tetlet.2009.01.135
● Daphnezomines T-V, alkaloids from Daphniphyllum humile
Kubota, T.; Suzuki, T.; Ishiuchi, K.; Kuhara, T.; Kobayashi, J.
Chem. Pharm. Bull. 2009, 57, 504–507. DOI: 10.1248/cpb.57.504
● Nagelamides Q and R, novel dimeric bromopyrrole alkaloids from sponges Agelas sp.
Araki, A.; Kubota, T.; Aoyama, K.; Mikami, Y.; Fromont, J.; Kobayashi, J.
Org. Lett. 2009, 11, 1785–1788. DOI: 10.1021/ol900328c
Kubota, T.; Suzuki, T.; Ishiuchi, K.; Kuhara, T.; Kobayashi, J.
Chem. Pharm. Bull. 2009, 57, 504–507. DOI: 10.1248/cpb.57.504
● Nagelamides Q and R, novel dimeric bromopyrrole alkaloids from sponges Agelas sp.
Araki, A.; Kubota, T.; Aoyama, K.; Mikami, Y.; Fromont, J.; Kobayashi, J.
Org. Lett. 2009, 11, 1785–1788. DOI: 10.1021/ol900328c
● Total synthesis and biological evaluation of amphidinolide V and analogues
Fürstner, A.; Flügge, S.; Larionov, O.; Takahashi, Y.; Kubota, T.; Kobayashi, J.
Chem. Eur. J. 2009, 15, 4011–4029. DOI: 10.1002/chem.200802068
● Petiolins D and E, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum
Tanaka, N.; Kubota, T.; Ishiyama, H.; Kashiwada, Y.; Takaishi, Y.; Ito, J.; Mikami, Y.; Shiro, M.; Kobayashi, J.
Heterocycles 2009, 79, 917–924. DOI: 10.3987/COM-08-S(D)64
● Naucleamide F, a new monoterpene indole alkaloid from Nauclea latifolia
Kakuguchi, Y.; Ishiyama, H.; Kubota, T.; Kobayashi, J.
Heterocycles 2009, 79, 765–771. DOI: 10.1248/cpb.51.58
● Bromopyrrole alkaloids from marine sponges of the genus Agelas
Yasuda, T.; Araki, A.; Kubota, T.; Ito, J.; Mikami, Y.; Fromont, J.; Kobayashi, J.
J. Nat. Prod. 2009, 72, 488–491. DOI: 10.1021/np800645q
● Nakijiquinones E and F, new dimeric sesquiterpenoid quinones from marine sponge
Takahashi, Y.; Kubota, T.; Kobayashi, J.
Bioorg. Med. Chem. 2009, 17, 2185–2188. DOI: 10.1016/j.bmc.2008.10.080
● Tyrokeradines A and B, new bromotyrosine alkaloids with an imidazolyl-quinolinone moiety from a Verongid sponge
Mukai, H.; Kubota, T.; Aoyama, K.; Mikami, Y.; Fromont, J.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2009, 19, 1337–1339. DOI: 10.1016/j.bmcl.2009.01.056
Fürstner, A.; Flügge, S.; Larionov, O.; Takahashi, Y.; Kubota, T.; Kobayashi, J.
Chem. Eur. J. 2009, 15, 4011–4029. DOI: 10.1002/chem.200802068
● Petiolins D and E, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum
Tanaka, N.; Kubota, T.; Ishiyama, H.; Kashiwada, Y.; Takaishi, Y.; Ito, J.; Mikami, Y.; Shiro, M.; Kobayashi, J.
Heterocycles 2009, 79, 917–924. DOI: 10.3987/COM-08-S(D)64
● Naucleamide F, a new monoterpene indole alkaloid from Nauclea latifolia
Kakuguchi, Y.; Ishiyama, H.; Kubota, T.; Kobayashi, J.
Heterocycles 2009, 79, 765–771. DOI: 10.1248/cpb.51.58
● Bromopyrrole alkaloids from marine sponges of the genus Agelas
Yasuda, T.; Araki, A.; Kubota, T.; Ito, J.; Mikami, Y.; Fromont, J.; Kobayashi, J.
J. Nat. Prod. 2009, 72, 488–491. DOI: 10.1021/np800645q
● Nakijiquinones E and F, new dimeric sesquiterpenoid quinones from marine sponge
Takahashi, Y.; Kubota, T.; Kobayashi, J.
Bioorg. Med. Chem. 2009, 17, 2185–2188. DOI: 10.1016/j.bmc.2008.10.080
● Tyrokeradines A and B, new bromotyrosine alkaloids with an imidazolyl-quinolinone moiety from a Verongid sponge
Mukai, H.; Kubota, T.; Aoyama, K.; Mikami, Y.; Fromont, J.; Kobayashi, J.
Bioorg. Med. Chem. Lett. 2009, 19, 1337–1339. DOI: 10.1016/j.bmcl.2009.01.056
● Total synthesis of amphidinolactone A and its absolute configuration
Hangyou, M.; Ishiyama, H.; Takahashi, Y.; Kubota, T.; Kobayashi, J.
Tetrahedron Lett. 2009, 50, 1475–477. DOI: 10.1016/j.tetlet.2009.01.065
● Zamamidine C, 3,4-dihydro-6-hydroxy-10,11-epoxymanzamine A, and 3,4-dihydromanzamine J N -oxide, new manzamine alkaloids from sponge Amphimedon sp.
Yamada, M.; Takahashi, Y.; Kubota, T.; Fromont, J.; Ishiyama, A.; Otoguro, K.; Yamada, H.; Ōmura, S.; Kobayashi, J.
Tetrahedron 2009, 65, 2313–2317. DOI: 10.1016/j.tet.2009.01.032
Tetrahedron 2009, 65, 6263. DOI: 10.1016/j.tet.2009.05.081
Hangyou, M.; Ishiyama, H.; Takahashi, Y.; Kubota, T.; Kobayashi, J.
Tetrahedron Lett. 2009, 50, 1475–477. DOI: 10.1016/j.tetlet.2009.01.065
● Zamamidine C, 3,4-dihydro-6-hydroxy-10,11-epoxymanzamine A, and 3,4-dihydromanzamine J N -oxide, new manzamine alkaloids from sponge Amphimedon sp.
Yamada, M.; Takahashi, Y.; Kubota, T.; Fromont, J.; Ishiyama, A.; Otoguro, K.; Yamada, H.; Ōmura, S.; Kobayashi, J.
Tetrahedron 2009, 65, 2313–2317. DOI: 10.1016/j.tet.2009.01.032
Tetrahedron 2009, 65, 6263. DOI: 10.1016/j.tet.2009.05.081
● Calyciphyllines N-P, alkaloids from Daphniphyllum calycinum
Yahata, H.; Kubota, T.; Kobayashi, J.
J. Nat. Prod. 2009, 72, 148–151. DOI: 10.1021/np800515s
Yahata, H.; Kubota, T.; Kobayashi, J.
J. Nat. Prod. 2009, 72, 148–151. DOI: 10.1021/np800515s
● Zamamidines A and B, new manzamine alkaloids from sponge Amphimedon species
Takahashi, Y.; Kubota, T.; Fromont, J.; Kobayashi, J.
Org. Lett. 2009, 11, 21–24. DOI: 10.1021/ol802251q
Takahashi, Y.; Kubota, T.; Fromont, J.; Kobayashi, J.
Org. Lett. 2009, 11, 21–24. DOI: 10.1021/ol802251q
2008
● Xestosaprol C, a new pentacyclic hydroquinone sulfate from a marine sponge Xestospongia sapra
Kubota, T.; Kon, Y.; Kobayashi, J.
Heterocycles 2008, 76, 1571–1575. DOI: 10.3987/COM-08-S(N)122
● Nagelamides M and N, new bromopyrrole alkaloids from sponge Agelas species
Kubota, T.; Araki, A.; Ito, J.; Mikami, Y.; Fromont, J.; Kobayashi, J.
Tetrahedron 2008, 64, 10810–10813. DOI: 10.1016/j.tet.2008.09.039
● Xestosaprol C, a new pentacyclic hydroquinone sulfate from a marine sponge Xestospongia sapra
Kubota, T.; Kon, Y.; Kobayashi, J.
Heterocycles 2008, 76, 1571–1575. DOI: 10.3987/COM-08-S(N)122
● Nagelamides M and N, new bromopyrrole alkaloids from sponge Agelas species
Kubota, T.; Araki, A.; Ito, J.; Mikami, Y.; Fromont, J.; Kobayashi, J.
Tetrahedron 2008, 64, 10810–10813. DOI: 10.1016/j.tet.2008.09.039
● Absolute stereochemistry of amphidinolide Q
Takahashi, Y.; Kubota, T.; Fukushi, E.; Kawabata, J.; Kobayashi, J.
Org. Lett. 2008, 10, 3709–3711. DOI: 10.1021/ol8013123
Takahashi, Y.; Kubota, T.; Fukushi, E.; Kawabata, J.; Kobayashi, J.
Org. Lett. 2008, 10, 3709–3711. DOI: 10.1021/ol8013123
● Nakijiquinones G-I, new sesquiterpenoid quinones from marine sponge
Takahashi, Y.; Kubota, T.; Ito, J.; Mikami, Y.; Fromont, J.; Kobayashi, J.
Bioorg. Med. Chem. 2008, 16, 7561–7564. DOI: 10.1016/j.bmc.2008.07.028
● Nagelamides K and L, dimeric bromopyrrole alkaloids from sponge Agelas species
Araki, A.; Kubota, T.; Tsuda, M.; Mikami, Y.; Fromont, J.; Kobayashi, J.
Org. Lett. 2008, 10, 2099–2102. DOI: 10.1021/ol8003904
Takahashi, Y.; Kubota, T.; Ito, J.; Mikami, Y.; Fromont, J.; Kobayashi, J.
Bioorg. Med. Chem. 2008, 16, 7561–7564. DOI: 10.1016/j.bmc.2008.07.028
● Nagelamides K and L, dimeric bromopyrrole alkaloids from sponge Agelas species
Araki, A.; Kubota, T.; Tsuda, M.; Mikami, Y.; Fromont, J.; Kobayashi, J.
Org. Lett. 2008, 10, 2099–2102. DOI: 10.1021/ol8003904
● Petiolins A-C, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum
Tanaka, N.; Kubota, T.; Ishiyama, H.; Araki, A.; Kashiwada, Y.; Takaishi, Y.; Mikami, Y.; Kobayashi, J.
Bioorg. Med. Chem. 2008, 16, 5619–5623. DOI: 10.1016/j.bmc.2008.03.076
● Nakinadines B-F: new pyridine alkaloids with a β-amino acid moiety from sponge Amphimedon sp.
Nishi, T.; Kubota, T.; Fromont, J.; Sasaki, T.; Kobayashi, J.
Tetrahedron 2008, 64, 3127–3232. DOI: 10.1016/j.tet.2008.01.111
● Calyciphyllines H-M, new Daphniphyllum alkaloids from Daphniphyllum calycinum
Saito, S.; Yahata, H.; Kubota, T.; Obara, Y.; Nakahata, N.; Kobayashi, J.
Tetrahedron 2008, 64, 1901–1908. DOI: 10.1016/j.tet.2007.11.087
2007
● Seragadine A, a β-carboline alkaloid from marine sponge
Nozawa, K.; Tsuda, M.; Kubota, T.; Fromont, J.; Kobayashi, J.
Heterocycles 2007, 74, 849–853. DOI: 10.3987/COM-07-S(W)77
● Lycopladine E, a new C16N1-type alkaloid from Lycopodium complanatum
Kubota, T.; Yahata, H.; Ishiuchi, K.; Obara, Y.; Nakahata, N.; Kobayashi, J.
Heterocycles 2007, 74, 843–848. DOI: 10.3987/COM-07-S(W)76
● Metachromins R-T, new sesquiterpenoids from marine sponge Spongia sp.
Takahashi, Y.; Yamada, M.; Kubota, T.; Fromont, J.; Kobayashi, J.
Chem. Pharm. Bull. 2007, 55, 1731–1733. DOI: 10.1248/cpb.55.1731
● Nitrogen-containing verticillene diterpenoids from Taiwanese soft coral Cespitularia taeniata
Shen, Y. C.; Cheng, Y. B.; Kobayashi, J.; Kubota, T.; Takahashi, Y.; Mikami, Y.; Ito, J.; Kuo, Y. H.
J. Nat. Prod. 2007, 70, 1961–1965. DOI: 10.1021/np078011u
● Sarusubine A, a new dimeric Lythraceae alkaloid from Lagerstroemia subcostata
Watanabe, K.; Kubota, T.; Shinzato, T.; Ito, J.; Mikami, Y.; Kobayashi, J.
Tetrahedron Lett. 2007, 48, 7502–7504. DOI: 10.1016/j.tetlet.2007.08.059
● Metachromins L-Q, new sesquiterpenoid quinones with an amino acid residue from sponge Spongia sp.
Takahashi, Y.; Kubota, T.; Fromont, J.; Kobayashi, J.
Tetrahedron 2007, 63, 8770–8773. DOI: 10.1016/j.tet.2007.06.031
● Calyciphylline G, a novel alkaloid with an unprecedented fused-hexacyclic skeleton from Daphniphyllum calycinum
Saito, S.; Kubota, T.; Kobayashi, J.
Tetrahedron Lett. 2007, 48, 5693–5695. DOI: 10.1016/j.tetlet.2007.05.172
Tanaka, N.; Kubota, T.; Ishiyama, H.; Araki, A.; Kashiwada, Y.; Takaishi, Y.; Mikami, Y.; Kobayashi, J.
Bioorg. Med. Chem. 2008, 16, 5619–5623. DOI: 10.1016/j.bmc.2008.03.076
● Nakinadines B-F: new pyridine alkaloids with a β-amino acid moiety from sponge Amphimedon sp.
Nishi, T.; Kubota, T.; Fromont, J.; Sasaki, T.; Kobayashi, J.
Tetrahedron 2008, 64, 3127–3232. DOI: 10.1016/j.tet.2008.01.111
● Calyciphyllines H-M, new Daphniphyllum alkaloids from Daphniphyllum calycinum
Saito, S.; Yahata, H.; Kubota, T.; Obara, Y.; Nakahata, N.; Kobayashi, J.
Tetrahedron 2008, 64, 1901–1908. DOI: 10.1016/j.tet.2007.11.087
2007
● Seragadine A, a β-carboline alkaloid from marine sponge
Nozawa, K.; Tsuda, M.; Kubota, T.; Fromont, J.; Kobayashi, J.
Heterocycles 2007, 74, 849–853. DOI: 10.3987/COM-07-S(W)77
● Lycopladine E, a new C16N1-type alkaloid from Lycopodium complanatum
Kubota, T.; Yahata, H.; Ishiuchi, K.; Obara, Y.; Nakahata, N.; Kobayashi, J.
Heterocycles 2007, 74, 843–848. DOI: 10.3987/COM-07-S(W)76
● Metachromins R-T, new sesquiterpenoids from marine sponge Spongia sp.
Takahashi, Y.; Yamada, M.; Kubota, T.; Fromont, J.; Kobayashi, J.
Chem. Pharm. Bull. 2007, 55, 1731–1733. DOI: 10.1248/cpb.55.1731
● Nitrogen-containing verticillene diterpenoids from Taiwanese soft coral Cespitularia taeniata
Shen, Y. C.; Cheng, Y. B.; Kobayashi, J.; Kubota, T.; Takahashi, Y.; Mikami, Y.; Ito, J.; Kuo, Y. H.
J. Nat. Prod. 2007, 70, 1961–1965. DOI: 10.1021/np078011u
● Sarusubine A, a new dimeric Lythraceae alkaloid from Lagerstroemia subcostata
Watanabe, K.; Kubota, T.; Shinzato, T.; Ito, J.; Mikami, Y.; Kobayashi, J.
Tetrahedron Lett. 2007, 48, 7502–7504. DOI: 10.1016/j.tetlet.2007.08.059
● Metachromins L-Q, new sesquiterpenoid quinones with an amino acid residue from sponge Spongia sp.
Takahashi, Y.; Kubota, T.; Fromont, J.; Kobayashi, J.
Tetrahedron 2007, 63, 8770–8773. DOI: 10.1016/j.tet.2007.06.031
● Calyciphylline G, a novel alkaloid with an unprecedented fused-hexacyclic skeleton from Daphniphyllum calycinum
Saito, S.; Kubota, T.; Kobayashi, J.
Tetrahedron Lett. 2007, 48, 5693–5695. DOI: 10.1016/j.tetlet.2007.05.172
● Amphidinolactone B, a new 26-membered macrolide from dinoflagellate Amphidinium sp.
Takahashi, Y.; Kubota, T.; Kobayashi, J.
J. Antibiot. 2007, 60, 376–379. DOI: 10.1038/ja.2007.51
● Nakinadine A, a novel bis-pyridine alkaloid with a β-amino acid moiety from sponge Amphimedon sp.
Kubota, T.; Nishi, T.; Fukushi, E.; Kawabata, J.; Fromont, J.; Kobayashi, J.
Tetrahedron Lett. 2007, 48, 4983–4985. DOI: 10.1016/j.tetlet.2007.05.121
Takahashi, Y.; Kubota, T.; Kobayashi, J.
J. Antibiot. 2007, 60, 376–379. DOI: 10.1038/ja.2007.51
● Nakinadine A, a novel bis-pyridine alkaloid with a β-amino acid moiety from sponge Amphimedon sp.
Kubota, T.; Nishi, T.; Fukushi, E.; Kawabata, J.; Fromont, J.; Kobayashi, J.
Tetrahedron Lett. 2007, 48, 4983–4985. DOI: 10.1016/j.tetlet.2007.05.121
● Nagelamide J, a novel dimeric bromopyrrole alkaloid from sponge Agelas species
Araki, A.; Tsuda, M.; Kubota, T.; Mikami, Y.; Fromont, J.; Kobayashi, J.
Org. Lett. 2007, 9, 2369–2371. DOI: 10.1021/ol0707867
Araki, A.; Tsuda, M.; Kubota, T.; Mikami, Y.; Fromont, J.; Kobayashi, J.
Org. Lett. 2007, 9, 2369–2371. DOI: 10.1021/ol0707867
● Calyciphyllines E and F, novel penta- and heptacyclic alkaloids from Daphniphyllum calycinum
Saito, S.; Kubota, T.; Kobayashi, J.
Tetrahedron Lett. 2007, 48, 3809–3812. DOI: 10.1016/j.tetlet.2007.03.156
Saito, S.; Kubota, T.; Kobayashi, J.
Tetrahedron Lett. 2007, 48, 3809–3812. DOI: 10.1016/j.tetlet.2007.03.156
● Calyciphylline D, a novel alkaloid with an unprecedented fused-pentacyclic skeleton from Daphniphyllum calycinum
Saito, S.; Kubota, T.; Fukushi, E.; Kawabata, J.; Zhang, H.; Kobayashi, J.
Org. Lett. 2007, 9, 1207–1209. DOI: 10.1021/ol0631455
Saito, S.; Kubota, T.; Fukushi, E.; Kawabata, J.; Zhang, H.; Kobayashi, J.
Org. Lett. 2007, 9, 1207–1209. DOI: 10.1021/ol0631455
● Amphidinolactone A, a new 13-membered macrolide from dinoflagellate Amphidinium sp.
Takahashi, Y.; Kubota, T.; Kobayashi, J.
Heterocycles 2007, 72, 567–572. DOI: 10.3987/COM-06-S(K)49
● Calyciphylline C, a novel Daphniphyllum alkaloid from Daphniphyllum calycinum
Saito, S.; Kubota, T.; Fukushi, E.; Kawabata, J.; Zhang, H.; Kobayashi, J.
Tetrahedron Lett. 2007, 48, 1587–1589. DOI: 10.1021/np800515s
Takahashi, Y.; Kubota, T.; Kobayashi, J.
Heterocycles 2007, 72, 567–572. DOI: 10.3987/COM-06-S(K)49
● Calyciphylline C, a novel Daphniphyllum alkaloid from Daphniphyllum calycinum
Saito, S.; Kubota, T.; Fukushi, E.; Kawabata, J.; Zhang, H.; Kobayashi, J.
Tetrahedron Lett. 2007, 48, 1587–1589. DOI: 10.1021/np800515s
● Complanadines C and D, new dimeric alkaloids from Lycopodium complanatum
Ishiuchi, K.; Kubota, T.; Mikami, Y.; Obara, Y.; Nakahata, N.; Kobayashi, J.
Bioorg. Med. Chem. 2007, 15, 413–417. DOI: 10.1016/j.bmc.2006.09.043
2006
● Lycovatine A, a C16N-type quaternary alkaloid from Lycopodium clavatum& var. robustum
Kubota, T.; Sunaura, T.; Morita, H.; Mikami, Y.; Hoshino, T.; Obara, Y.; Nakahata, N.; Kobayashi, J.
Heterocycles 2006, 69, 469–474. DOI: 10.3987/COM-06-S(O)21
● Brasilicardin A, a natural immunosuppressant, targets amino acid transport system L
Usui, T.; Nagumo, Y.; Watanabe, A.; Kubota, T.; Komatsu, K.; Kobayashi, J.; Osada, H.
Chem. Biol. 2006, 13, 1153–1160. DOI :10.1016/j.chembiol.2006.09.006
● Pyrinadines B-G, new bis-pyridine alkaloids with an azoxy moiety from sponge Cribrochalina sp.
Kariya, Y.; Kubota, T.; Fromont, J.; Kobayashi, J.
Bioorg. Med. Chem. 2006, 14, 8415–8419. DOI: 10.1016/j.bmc.2006.08.045
● Paratunamides A-D, oxindole alkaloids from Cinnamodendron axillare
Kagata, T.; Saito, S.; Shigemori, H.; Ohsaki, A.; Ishiyama, H.; Kubota, T.; Kobayashi, J.
J. Nat. Prod. 2006, 69, 1517–1521. DOI: 10.1021/np0602968
● Amphidinin B, a new polyketide metabolite from marine dinoflagellate Amphidinium sp.
Kubota, T.; Endo, T.; Takahashi, Y.; Tsuda, M.; Kobayashi, J.
J. Antibiot. 2006, 59, 512–516. DOI: 10.1038/ja.2006.72
● Determination of the cryptic stereochemistry of the first PKS chain-extension step in ansamitocin biosynthesis by Actinosynnema pretiosum
Kubota, T.; Brünjes, M.; Frenzel, T.; Xu, J.; Kirschning, A.; Floss, H. G.
ChemBioChem 2006, 7, 1221–1225. DOI: 10.1002/cbic.200500506
● Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum
Ishiuchi, K.; Kubota, T.; Hoshino, T.; Obara, Y.; Nakahata, N.; Kobayashi, J.
Bioorg. Med. Chem. 2006, 14, 5995–6000. DOI: 10.1016/j.bmc.2006.05.028
● Cloning of polyketide synthase genes from amphidinolide-producing dinoflagellate Amphidinium sp.
Kubota, T.; Iinuma, Y.; Kobayashi, J.
Biol. Pharm. Bull. 2006, 29, 1314–1318. DOI: 10.1248/bpb.29.1314
● Iejimalides show anti-osteoclast activity via V-ATPase inhibition
Kazami, S.; Muroi, M.; Kawatani, M.; Kubota, T.; Usui, T.; Kobayashi, J.; Osada, H.
Biosci. Biotechnol. Biochem. 2006, 70, 1364–1370. DOI: 10.1271/bbb.50644
● Amphezonol A, a novel polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp.
Kubota, T.; Sakuma, Y.; Shimbo, K.; Tsuda, M.; Nakano, M.; Uozumi, Y.; Kobayashi, J.
Tetrahedron Lett. 2006, 47, 4369–4371. DOI: 10.1016/j.tetlet.2006.04.094
● Daphtenidines A-D, new Daphniphyllum alkaloids from Daphniphyllum teijsmannii
Kubota, T.; Matsuno, Y.; Morita, H.; Shinzato, T.; Sekiguchi, M.; Kobayashi, J.
Tetrahedron 2006, 62, 4743–4748. DOI: 10.1016/j.tet.2006.03.040
● Lycopladine A, a new C16N alkaloid from Lycopodium complanatum
Ishiuchi, K.; Kubota, T.; Morita, H.; Kobayashi, J.
Tetrahedron Lett. 2006, 47, 3287–3289. DOI: 10.1016/j.tetlet.2006.03.027
Ishiuchi, K.; Kubota, T.; Mikami, Y.; Obara, Y.; Nakahata, N.; Kobayashi, J.
Bioorg. Med. Chem. 2007, 15, 413–417. DOI: 10.1016/j.bmc.2006.09.043
2006
● Lycovatine A, a C16N-type quaternary alkaloid from Lycopodium clavatum& var. robustum
Kubota, T.; Sunaura, T.; Morita, H.; Mikami, Y.; Hoshino, T.; Obara, Y.; Nakahata, N.; Kobayashi, J.
Heterocycles 2006, 69, 469–474. DOI: 10.3987/COM-06-S(O)21
● Brasilicardin A, a natural immunosuppressant, targets amino acid transport system L
Usui, T.; Nagumo, Y.; Watanabe, A.; Kubota, T.; Komatsu, K.; Kobayashi, J.; Osada, H.
Chem. Biol. 2006, 13, 1153–1160. DOI :10.1016/j.chembiol.2006.09.006
● Pyrinadines B-G, new bis-pyridine alkaloids with an azoxy moiety from sponge Cribrochalina sp.
Kariya, Y.; Kubota, T.; Fromont, J.; Kobayashi, J.
Bioorg. Med. Chem. 2006, 14, 8415–8419. DOI: 10.1016/j.bmc.2006.08.045
● Paratunamides A-D, oxindole alkaloids from Cinnamodendron axillare
Kagata, T.; Saito, S.; Shigemori, H.; Ohsaki, A.; Ishiyama, H.; Kubota, T.; Kobayashi, J.
J. Nat. Prod. 2006, 69, 1517–1521. DOI: 10.1021/np0602968
● Amphidinin B, a new polyketide metabolite from marine dinoflagellate Amphidinium sp.
Kubota, T.; Endo, T.; Takahashi, Y.; Tsuda, M.; Kobayashi, J.
J. Antibiot. 2006, 59, 512–516. DOI: 10.1038/ja.2006.72
● Determination of the cryptic stereochemistry of the first PKS chain-extension step in ansamitocin biosynthesis by Actinosynnema pretiosum
Kubota, T.; Brünjes, M.; Frenzel, T.; Xu, J.; Kirschning, A.; Floss, H. G.
ChemBioChem 2006, 7, 1221–1225. DOI: 10.1002/cbic.200500506
● Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum
Ishiuchi, K.; Kubota, T.; Hoshino, T.; Obara, Y.; Nakahata, N.; Kobayashi, J.
Bioorg. Med. Chem. 2006, 14, 5995–6000. DOI: 10.1016/j.bmc.2006.05.028
● Cloning of polyketide synthase genes from amphidinolide-producing dinoflagellate Amphidinium sp.
Kubota, T.; Iinuma, Y.; Kobayashi, J.
Biol. Pharm. Bull. 2006, 29, 1314–1318. DOI: 10.1248/bpb.29.1314
● Iejimalides show anti-osteoclast activity via V-ATPase inhibition
Kazami, S.; Muroi, M.; Kawatani, M.; Kubota, T.; Usui, T.; Kobayashi, J.; Osada, H.
Biosci. Biotechnol. Biochem. 2006, 70, 1364–1370. DOI: 10.1271/bbb.50644
● Amphezonol A, a novel polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp.
Kubota, T.; Sakuma, Y.; Shimbo, K.; Tsuda, M.; Nakano, M.; Uozumi, Y.; Kobayashi, J.
Tetrahedron Lett. 2006, 47, 4369–4371. DOI: 10.1016/j.tetlet.2006.04.094
● Daphtenidines A-D, new Daphniphyllum alkaloids from Daphniphyllum teijsmannii
Kubota, T.; Matsuno, Y.; Morita, H.; Shinzato, T.; Sekiguchi, M.; Kobayashi, J.
Tetrahedron 2006, 62, 4743–4748. DOI: 10.1016/j.tet.2006.03.040
● Lycopladine A, a new C16N alkaloid from Lycopodium complanatum
Ishiuchi, K.; Kubota, T.; Morita, H.; Kobayashi, J.
Tetrahedron Lett. 2006, 47, 3287–3289. DOI: 10.1016/j.tetlet.2006.03.027
● Manzamenones inhibit T-cell protein tyrosine phosphatase
Wakuda, Y.; Kubota, T.; Shima, H.; Okada, T.; Mitsuhashi, S.; Aoki, N.; Kikuchi, K.; Kobayashi, J.
Mar. Drugs 2006, 4, 9–14. DOI: 10.3390/md401009
● Pyrinadine A, a novel pyridine alkaloid with an azoxy moiety from sponge Cribrochalina sp.
Kariya, Y.; Kubota, T.; Fromont, J.; Kobayashi, J.
Tetrahedron Lett. 2006, 47, 997–998. DOI: 10.1016/j.tetlet.2005.11.163
Wakuda, Y.; Kubota, T.; Shima, H.; Okada, T.; Mitsuhashi, S.; Aoki, N.; Kikuchi, K.; Kobayashi, J.
Mar. Drugs 2006, 4, 9–14. DOI: 10.3390/md401009
● Pyrinadine A, a novel pyridine alkaloid with an azoxy moiety from sponge Cribrochalina sp.
Kariya, Y.; Kubota, T.; Fromont, J.; Kobayashi, J.
Tetrahedron Lett. 2006, 47, 997–998. DOI: 10.1016/j.tetlet.2005.11.163
2005
● Luteophanol D, new polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp.
Kubota, T.; Takahashi, A.; Tsuda, M.; Kobayashi, J.
Mar. Drugs 2005, 3, 113–118. DOI: 10.3390/md304113
2004
● Amphidinolide C2, new macrolide from marine dinoflagellate Amphidinium species
Kubota, T.; Sakuma, Y.; Tsuda, M.; Kobayashi, J.
Mar. Drugs 2004 2, 83–87. DOI: 10.3390/md203083
2003
● Absolute stereochemistry of amphidinolide C: synthesis of C-1-C-10 and C-17-C-29 segments
Kubota, T.; Tsuda, M.; Kobayashi, J.
Tetrahedron 2003, 59, 1613–1625. DOI: 10.1016/S0040-4020(03)00142-X
2002
● Absolute stereochemistry of amphidinolide E
Kubota, T.; Tsuda, M.; Kobayashi, J.
J. Org. Chem. 2002, 67, 1651–1656. DOI: 10.1021/jo016326n
● Luteophanol D, new polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp.
Kubota, T.; Takahashi, A.; Tsuda, M.; Kobayashi, J.
Mar. Drugs 2005, 3, 113–118. DOI: 10.3390/md304113
2004
● Amphidinolide C2, new macrolide from marine dinoflagellate Amphidinium species
Kubota, T.; Sakuma, Y.; Tsuda, M.; Kobayashi, J.
Mar. Drugs 2004 2, 83–87. DOI: 10.3390/md203083
2003
● Absolute stereochemistry of amphidinolide C: synthesis of C-1-C-10 and C-17-C-29 segments
Kubota, T.; Tsuda, M.; Kobayashi, J.
Tetrahedron 2003, 59, 1613–1625. DOI: 10.1016/S0040-4020(03)00142-X
2002
● Absolute stereochemistry of amphidinolide E
Kubota, T.; Tsuda, M.; Kobayashi, J.
J. Org. Chem. 2002, 67, 1651–1656. DOI: 10.1021/jo016326n
2001
● Biosynthetic study of amphidinolide B
Tsuda. M.; Kubota, T.; Sakuma, Y.; Kobayashi, J.
Chem. Pharm. Bull. 2001, 49, 1366–1367. DOI: 10.1248/cpb.49.1366
● Amphidinolide T5, a new 19-membered macrolide from a dinoflagellate and X-ray structure of amphidinolide T1
Kubota, T.; Endo, T.; Tsuda, M.; Shiro, M.; Kobayashi, J.
Tetrahedron 2001, 57, 6175–6179. DOI: 10.1016/S0040-4020(01)00591-9
● Biosynthetic study of amphidinolide B
Tsuda. M.; Kubota, T.; Sakuma, Y.; Kobayashi, J.
Chem. Pharm. Bull. 2001, 49, 1366–1367. DOI: 10.1248/cpb.49.1366
● Amphidinolide T5, a new 19-membered macrolide from a dinoflagellate and X-ray structure of amphidinolide T1
Kubota, T.; Endo, T.; Tsuda, M.; Shiro, M.; Kobayashi, J.
Tetrahedron 2001, 57, 6175–6179. DOI: 10.1016/S0040-4020(01)00591-9
● Biosynthetic study of amphidinolide C
Kubota, T.; Tsuda, M.; Kobayashi, J.
Tetrahedron 2001, 57, 5975–5977. DOI: 10.1016/S0040-4020(01)00556-7
● Absolute stereochemistry of amphidinolide C
Kubota, T.; Tsuda, M.; Kobayashi, J.
Org. Lett. 2001, 3, 1363–1366. DOI: 10.1021/ol015741z
Kubota, T.; Tsuda, M.; Kobayashi, J.
Tetrahedron 2001, 57, 5975–5977. DOI: 10.1016/S0040-4020(01)00556-7
● Absolute stereochemistry of amphidinolide C
Kubota, T.; Tsuda, M.; Kobayashi, J.
Org. Lett. 2001, 3, 1363–1366. DOI: 10.1021/ol015741z
● Amphidinolides T2, T3, and T4, new 19-membered macrolides from the dinoflagellate Amphidinium sp. and the biosynthesis of amphidinolide T1
Kobayashi, J.; Kubota, T.; Endo, T.; Tsuda, M.
J. Org. Chem. 2001, 66, 134–142. DOI: 10.1021/jo005607c
Kobayashi, J.; Kubota, T.; Endo, T.; Tsuda, M.
J. Org. Chem. 2001, 66, 134–142. DOI: 10.1021/jo005607c
2000
● Ma'edamines A and B, cytotoxic bromotyrosine alkaloids with a unique 2(1H)pyrazinone ring from sponge Suberea sp.
Hirano, K.; Kubota, T.; Tsuda, M.; Mikami, Y.; Watanabe, K.; Fromont, J.; Kobayashi, J.
Tetrahedron 2000, 56, 8107–8110. DOI: 10.1016/S0040-4020(00)00732-8
● Ma'edamines A and B, cytotoxic bromotyrosine alkaloids with a unique 2(1H)pyrazinone ring from sponge Suberea sp.
Hirano, K.; Kubota, T.; Tsuda, M.; Mikami, Y.; Watanabe, K.; Fromont, J.; Kobayashi, J.
Tetrahedron 2000, 56, 8107–8110. DOI: 10.1016/S0040-4020(00)00732-8
● Colopsinols D and E, new polyhydroxyl linear carbon chain compounds from marine dinoflagellate Amphidinium sp.
Kubota, T.; Tsuda, M.; Takahashi, M.; Ishibashi, M.; Oka, S.; Kobayashi, J.
Chem. Pharm. Bull. 2000, 48, 1447–1451. DOI: 10.1248/cpb.48.1447
● Pyrinodemin B-D, potent cytotoxic bis-pyridine alkaloid from marine sponge Amphimedon sp.
Hirano, K.; Kubota, T.; Tsuda, M.; Mikami, Y.; Kobayashi, J.
Chem. Pharm. Bull. 2000, 48, 974–977. DOI: 10.1248/cpb.48.974
● Amphidinolide V, novel 14-membered macroride from marine dinoflagellate Amphidinium sp.
Kubota, T.; Tsuda, M.; Kobayashi, J.
Tetrahedron Lett. 2000, 41, 713–716. DOI: 10.1016/S0040-4039(99)02170-X
Kubota, T.; Tsuda, M.; Takahashi, M.; Ishibashi, M.; Oka, S.; Kobayashi, J.
Chem. Pharm. Bull. 2000, 48, 1447–1451. DOI: 10.1248/cpb.48.1447
● Pyrinodemin B-D, potent cytotoxic bis-pyridine alkaloid from marine sponge Amphimedon sp.
Hirano, K.; Kubota, T.; Tsuda, M.; Mikami, Y.; Kobayashi, J.
Chem. Pharm. Bull. 2000, 48, 974–977. DOI: 10.1248/cpb.48.974
● Amphidinolide V, novel 14-membered macroride from marine dinoflagellate Amphidinium sp.
Kubota, T.; Tsuda, M.; Kobayashi, J.
Tetrahedron Lett. 2000, 41, 713–716. DOI: 10.1016/S0040-4039(99)02170-X
1999
● Colopsinols B and C, new long chain polyhydroxyl compounds from cultured marine dinoflagellate Amphidinium sp.
Kubota, T.; Tsuda, M.; Takahashi, M.; Ishibashi, M.; Naoki, H.; Kobayashi, J.
J. Chem. Soc., Perkin Trans. 1 1999, 3483–3488. DOI: 10.1039/A906296C
● Two theonellapeptolide congeners from marine sponge Theonella sp.
Tsuda, M.; Shimbo, K.; Kubota, T.; Mikami, Y.; Kobayashi, J.
Tetrahedron 1999, 55, 10305–10314. DOI: 10.1016/S0040-4020(99)00586-4
● Pyrinodemin A, a cytotoxic pyridine alkaloid with an isoxazolidine moiety from sponge Amphimedon sp.
Tsuda, M.; Hirano, K.; Kubota, T.; Kobayashi, J.
Tetrahedron Lett. 1999, 40, 4819–4820. DOI: 10.1016/S0040-4039(99)00852-7
● Colopsinol A, a novel polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp.
Kobayashi, J.; Kubota, T.; Takahashi, M.; Ishibashi, M.; Tsuda, M.; Naoki, H.
J. Org. Chem. 1999, 64, 1478–1482. DOI: 10.1021/jo981882b
● Colopsinols B and C, new long chain polyhydroxyl compounds from cultured marine dinoflagellate Amphidinium sp.
Kubota, T.; Tsuda, M.; Takahashi, M.; Ishibashi, M.; Naoki, H.; Kobayashi, J.
J. Chem. Soc., Perkin Trans. 1 1999, 3483–3488. DOI: 10.1039/A906296C
● Two theonellapeptolide congeners from marine sponge Theonella sp.
Tsuda, M.; Shimbo, K.; Kubota, T.; Mikami, Y.; Kobayashi, J.
Tetrahedron 1999, 55, 10305–10314. DOI: 10.1016/S0040-4020(99)00586-4
● Pyrinodemin A, a cytotoxic pyridine alkaloid with an isoxazolidine moiety from sponge Amphimedon sp.
Tsuda, M.; Hirano, K.; Kubota, T.; Kobayashi, J.
Tetrahedron Lett. 1999, 40, 4819–4820. DOI: 10.1016/S0040-4039(99)00852-7
● Colopsinol A, a novel polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp.
Kobayashi, J.; Kubota, T.; Takahashi, M.; Ishibashi, M.; Tsuda, M.; Naoki, H.
J. Org. Chem. 1999, 64, 1478–1482. DOI: 10.1021/jo981882b
1998
● Luteophanols B and C, new polyhydroxyl compounds from marine dinoflagellate Amphidinium sp.
Kubota, T.; Tsuda, M.; Doi, Y.; Takahashi, A.; Nakamichi, H.; Ishibashi, M.; Fukushi, E.; Kawabata, J.; Kobayashi, J.
Tetrahedron 1998, 54, 14455–14464. DOI: 10.1016/S0040-4020(98)00898-9
● Luteophanols B and C, new polyhydroxyl compounds from marine dinoflagellate Amphidinium sp.
Kubota, T.; Tsuda, M.; Doi, Y.; Takahashi, A.; Nakamichi, H.; Ishibashi, M.; Fukushi, E.; Kawabata, J.; Kobayashi, J.
Tetrahedron 1998, 54, 14455–14464. DOI: 10.1016/S0040-4020(98)00898-9